A Capsulate on Nutrigenomics in Periodontitis (Chawla et al, 2018)Periodontal disease is an infectious process which occurs with the presence of bacteria and host response in the tissues surrounding the teeth and is further affected and modified by other local, environmental and genetic factors. This article summarizes the recent information regarding the nutrient-gene interactions and how diet triggers the underlying process of severe periodontitis.
Common Genetic Variation and Breast Cancer Risk - Past, present, and future (Lilyquist et al, 2018) To date, 182 breast cancer susceptibility SNPs have been identified for breast cancer, increasing understanding of the heritability of breast cancer. The combined effect of these SNPs in PRS models may pave the way to tailored screening and intervention strategies in the general population as well as in carriers of deleterious mutations in predisposition genes (e.g., BRCA1 and BRCA2).
Association of Raynaud’s phenomenon with a polymorphism in the NOS1 gene(Munir et al., 2018) This paper concluded that a SNP in the NOS1 gene was significantly associated with Raynaud's. This particular gene enables the synthesis of nitric oxide (NO), which is responsible for mediating vasodilation following cold exposure. If the NOS1 gene is mutated however, NO isn't produced and the blood vessels remain constricted, thus resulting in a limited blood flow and associated Raynaud's symptoms.
Epigenetic alterations in depression and antidepressant treatment (Menke and Binder, 2014) Epigenetics may provide new insight into pathophysiology of major depression and may yield novel biomarkers for diagnosis and treatment response. Reflecting environmental factors as well as genetic contribution to the development of major depression, epigenetic mechanisms may help in dissecting the complex phenotype of major depression.
Nutrigenomics and Cancer Prevention (Nicastro et al, 2012)Findings to date demonstrate that nutrigenomics and the downstream events can have a significant impact on the relationship between dietary exposures and cancer risk/tumour behaviour.
Nutrigenomics, Vitamin D and Cancer Prevention (Davis and Milner, 2011) It is already abundantly clear that genetics and nutrient-nutrient interactions can influence the overall response to vitamin D. While additional and widespread food fortification might reduce the risk of some cancers, it may also precipitate issues in others.
Gene Variants Associated With Ischemic Stroke: The Cardiovascular Health Study(Luke et al, 2009) We found that a subset of gene variants previously associated with CHD in antecedent studies were also associated with incident ischemic stroke in CHS; however, in CHS, none of these SNPs were associated with both myocardial infarction and stroke. Notably, the Val allele of the Val12Met SNP in ABCG2 (which encodes a transporter of sterols and anticancer drugs) was associated with increased risk of incident ischemic stroke in both white and black participants of CHS.
Nutrigenomics: The Genome–Food Interface (Mead, 2007) Nutrigenomics will help usher in the development of new functional foods and supplements for genome health that can be mixed and matched so that overall nutritional intake is appropriately tailored to an individual’s genotype and genome status.