Nutrigenomics related research papers - CNSLab

Nutrigenomics related research papers

  1. A Capsulate on Nutrigenomics in Periodontitis (Chawla et al, 2018)                       Periodontal disease is an infectious process which occurs with the presence of bacteria and host response in the tissues surrounding the teeth and is further affected and modified by other local, environmental and genetic factors. This article summarizes the recent information regarding the nutrient-gene interactions and how diet triggers the underlying process of severe periodontitis.
  2. Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways (Howard et al, 2018)              This study describes a large analysis of depression-related phenotypes using a single population-based cohort. Up to 322,580 individuals from the UK Biobank cohort were used to test the effect of 7,666,894 genetic variants on three depression phenotypes.
  3. Common Genetic Variation and Breast Cancer Risk - Past, present, and future (Lilyquist et al, 2018)                                                                                                                                             To date, 182 breast cancer susceptibility SNPs have been identified for breast cancer, increasing understanding of the heritability of breast cancer. The combined effect of these SNPs in PRS models may pave the way to tailored screening and intervention strategies in the general population as well as in carriers of deleterious mutations in predisposition genes (e.g., BRCA1 and BRCA2).  
  4. Association of Raynaud’s phenomenon with a polymorphism in the NOS1 gene (Munir et al., 2018)                                                                                                                                              This paper concluded that a SNP in the NOS1 gene was significantly associated with Raynaud's. This particular gene enables the synthesis of nitric oxide (NO), which is responsible for mediating vasodilation following cold exposure. If the NOS1 gene is mutated however, NO isn't produced and the blood vessels remain constricted, thus resulting in a limited blood flow and associated Raynaud's symptoms. 
  5. The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer’s disease                                   (Burfeind et al, 2017)                                                                                                                                             Burfeind and collegues (2017) identified five SNPs in the AQP4 gene associated with the rate of functional and cognitive decline in Alzheimer's Disease. This study was the first to investigate the association between mutations in this gene and functional outcomes in Alzheimers's Disease, with the results identifying a potential biomarker for cognitive decline in this form of dementia, as well as a possible therapeutic target.
  6. Nutrigenomics and Nutrigenetics: New Insight in Disease Prevention and Cure  (Sharma and Dwived, 2017)                                                                                                         Nutrigenomics will help in evaluating the individual nutritional needs based on the genetic profile of the individual (personalised diet) as well as help in curing and preventing the chronic diseases.
  7. MTHFR Gene Polymorphism Positive Treatment-Resistant Depression: Prevalence and Treatment Recommendations (Duprey, 2016)                                             Depressed patients identified as treatment resistant have a 76% chance of having the MTHFR mutation with a 77% chance of being heterozygous. This warrants specific treatment strategies.
  8. The role of nutrition related genes and nutrigenetics in understanding the pathogenesis of cancer (Elsamanoudy et al, 2016)                                                                        The aim of this work is to clarify the basic knowledge about the vital role of nutrition-related genes in various disease states, especially cancer, and to identify nutrigenetics as a new concept that could highlight the relation between nutrition and gene expression. This may help to understand the mechanism and pathogenesis of cancer.
  9. Epigenetic alterations in depression and antidepressant treatment                            (Menke and Binder, 2014)                                                                                                                         Epigenetics may provide new insight into pathophysiology of major depression and may yield novel biomarkers for diagnosis and treatment response. Reflecting environmental factors as well as genetic contribution to the development of major depression, epigenetic mechanisms may help in dissecting the complex phenotype of major depression. 
  10. Nutrigenomics and Cancer Prevention (Nicastro et al, 2012)                                      Findings to date demonstrate that nutrigenomics and the downstream events can have a significant impact on the relationship between dietary exposures and cancer risk/tumour behaviour.
  11. Eating disorders and the intestinal microbiota: Mechanisms of energy homeostasis and behavioral influence (Campbell et al, 2011)                             Understanding the relationship between epigenetic processes and the risk of an eating disorder opens possibilities for preventive and/or therapeutic interventions.
  12. Nutrigenomics, Vitamin D and Cancer Prevention (Davis and Milner, 2011)               It is already abundantly clear that genetics and nutrient-nutrient interactions can influence the overall response to vitamin D. While additional and widespread food fortification might reduce the risk of some cancers, it may also precipitate issues in others. 
  13. Gene Variants Associated With Ischemic Stroke: The Cardiovascular Health Study (Luke et al, 2009)                                                                                                                                     We found that a subset of gene variants previously associated with CHD in antecedent studies were also associated with incident ischemic stroke in CHS; however, in CHS, none of these SNPs were associated with both myocardial infarction and stroke. Notably, the Val allele of the Val12Met SNP in ABCG2 (which encodes a transporter of sterols and anticancer drugs) was associated with increased risk of incident ischemic stroke in both white and black participants of CHS.
  14. Nutrigenomics: The Genome–Food Interface (Mead, 2007)                                          Nutrigenomics will help usher in the development of new functional foods and supplements for genome health that can be mixed and matched so that overall nutritional intake is appropriately tailored to an individual’s genotype and genome status.